Kozlov V K, Chepurov A K
Biull Eksp Biol Med. 1978 Feb;85(2):132-6.
The studies were carried out to verify the hypothesis on the structural-functional organization of the hemostatic clot. For this purpose the influence of the platelets and their aggregate condition on the mechanical properties of the clot was investigated. Redistribution of platelets into aggregated, caused by addition of ADP and mixing, led to the inhibition of the clot retraction. This was reflected in the form of reduction of am on the thromboelastogram. Simultaneous recording of thrombloelastogram, coagulbbogram, and platelet degranulation demonstrated that processes of viscid metamorphosis of platelets and fibrin filaments sedimentation were followed by active clot contraction. The clot is a fibrin-platelet structure whose nodes contain blood platelets, and cells--the rest blood elements. The clot retraction takes place due to contractile properties of platelets.
进行这些研究是为了验证关于止血凝块结构功能组织的假设。为此，研究了血小板及其聚集状态对凝块力学性能的影响。添加ADP并混合导致血小板重新分布成聚集状态，从而抑制了凝块回缩。这在血栓弹力图上表现为振幅降低的形式。同时记录血栓弹力图、凝血图和血小板脱颗粒情况表明，血小板的粘性变形和纤维蛋白丝沉降过程之后是活跃的凝块收缩。凝块是一种纤维蛋白-血小板结构，其节点包含血小板和细胞——其余血液成分。凝块回缩是由于血小板的收缩特性而发生的。
