Shults C W, Quirion R, Jensen R T, Moody T W, O'Donohue T L, Chase T N
Peptides. 1982 Nov-Dec;3(6):1073-5. doi: 10.1016/0196-9781(82)90076-6.
This paper describes a method for localization of substance P receptors in the rat central nervous system using 125I labeled substance P in an autoradiographic procedure. Particularly high densities of substance P receptors were observed in the olfactory bulb, dentate gyrus, amygdala, superior colliculus, and locus coeruleus. Surprisingly low densities of substance P receptors were found in the substantia nigra pars reticulata, a region which contains high concentrations of substance P.
本文描述了一种在大鼠中枢神经系统中使用放射性自显影技术，以125I标记的P物质来定位P物质受体的方法。在嗅球、齿状回、杏仁核、上丘和蓝斑中观察到P物质受体的密度特别高。令人惊讶的是，在黑质网状部发现P物质受体的密度很低，而该区域含有高浓度的P物质。
