• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of glutamic acid diethylester on (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid-induced changes of body temperature in rats.

作者信息

Turski W, Czuczwar S J, Turski L, Kleinrok Z

出版信息

Pol J Pharmacol Pharm. 1982;34(1-3):161-7.

PMID:6300814
Abstract

A low dose (1 microgram) of intracerebroventricularly injected (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) produced a hyperthermic response in rats, while a high dose of AMPA (2.5 micrograms), similarly to kainic acid (0.1 microgram) produced a biphasic effect: short-lasting hypothermia followed by hyperthermia. These effects on body temperature were not affected by pretreatment with 200 mg/kg ip of glutamic acid diethylester (GDEE), which by itself, produced a significant hypothermia. The results indicate that the effects of kainic acid and AMPA on body temperature are not mediated by GDEE-sensitive glutamate receptors.

摘要

相似文献

1
Effect of glutamic acid diethylester on (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid-induced changes of body temperature in rats.
Pol J Pharmacol Pharm. 1982;34(1-3):161-7.
2
(RS)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid: wet dog shakes, catalepsy and body temperature changes in rats.（RS）-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸：大鼠的湿狗样抖动、僵住症和体温变化
Pharmacol Biochem Behav. 1981 Oct;15(4):545-9. doi: 10.1016/0091-3057(81)90205-7.
3
Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens.
Pharmacol Biochem Behav. 1988 Jun;30(2):379-84. doi: 10.1016/0091-3057(88)90471-6.
4
Effects of morphine and nalorphine on kainic acid-induced hypothermia in rats.吗啡和烯丙吗啡对大鼠海人酸诱导的体温过低的影响。
Psychopharmacology (Berl). 1981;72(2):211-4. doi: 10.1007/BF00431659.
5
Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats.向大鼠下丘脑外侧注射谷氨酸、红藻氨酸、D，L-α-氨基-3-羟基-5-甲基异恶唑丙酸或N-甲基-D-天冬氨酸会迅速引发强烈的短暂进食行为。
Brain Res. 1993 Jun 4;613(1):88-95. doi: 10.1016/0006-8993(93)90458-y.
6
AMPA, kainic acid, and N-methyl-D-aspartic acid stimulate locomotor activity after injection into the substantia innominata/lateral preoptic area.将α-氨基-3-羟基-5-甲基-4-异恶唑丙酸、红藻氨酸和N-甲基-D-天冬氨酸注射到无名质/外侧视前区后，会刺激运动活动。
Pharmacol Biochem Behav. 1989 Sep;34(1):101-6. doi: 10.1016/0091-3057(89)90360-2.
7
Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones.谷氨酸类似物AMPA及其与拮抗剂的相互作用对培养的大鼠脊髓和脑干神经元的影响。
Neurosci Lett. 1983 Mar 28;36(1):59-62. doi: 10.1016/0304-3940(83)90486-x.
8
The ionic mechanisms associated with the excitatory response of kainate, L-glutamate, quisqualate, ibotenate, AMPA and methyltetrahydrofolate on leech Retzius cells.与红藻氨酸、L-谷氨酸、quisqualate、鹅膏蕈氨酸、AMPA和甲基四氢叶酸对水蛭Retzius细胞的兴奋性反应相关的离子机制。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):115-26. doi: 10.1016/0742-8413(84)90139-7.
9
(2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors.(2S,4R)-4-甲基谷氨酸（SYM 2081）：一种对红藻氨酸受体具有选择性、高亲和力的配体。
J Pharmacol Exp Ther. 1997 Jan;280(1):422-7.
10
Dipsogenic effects of excitatory amino acid agonists in pigeons.
J Pharmacol Exp Ther. 1993 Feb;264(2):918-21.