[Effect of gamma-aminobutyric acid derivatives on sleep disorders in neuroses].

Electropolygraphic studies showed that under gamma-amino-butyric acid (GABA) derivatives various neurotic patients with sleep disorders had a tendency towards an increase in total sleep duration due to an accretion of basic sleep stages (the 2nd stage, delta-sleep, and rapid sleep), a statistically significant reduction in the number of spontaneous wake-ups, time of awakedness during night and the movements activation index. A detailed analysis of some electrographic data within the sleep stages revealed a tendency towards an increase in number of the 2nd stage sleep spindles, of delta-index in the 3rd and 4th sleep stages, as well as an increase in the average readings of rapid eye movements in the absence of any marked changes in their specific occurrence per time unit. GABA derivatives in the used dosage caused similar changes in the sleep patterns in case of its disturbances, with a relatively more pronounced action of sodium oxybutyrate.