Polyansky N B, Smirnov L D, Shvedova A A, Kagan V E, Tkachuk V A
Vopr Med Khim. 1983 Jan-Feb;29(1):123-7.
3-Hydroxypyridines, which are inhibitors of cyclic nucleotide phosphodiesterase, affected reversibly and non-competitively the enzyme molecule as compared with cAMP. A number of substances was found exhibiting high inhibitory and antioxidant activities, high inhibitory and low antioxidant activities, as well as low inhibitory and high antioxidant activities. Elucidation of the 3-hydroxypyridines action via antioxidant or phosphodiesterase pathways became possible.
3-羟基吡啶是环核苷酸磷酸二酯酶的抑制剂，与环磷酸腺苷（cAMP）相比，它对酶分子产生可逆的非竞争性影响。发现了许多具有高抑制活性和高抗氧化活性、高抑制活性和低抗氧化活性以及低抑制活性和高抗氧化活性的物质。通过抗氧化或磷酸二酯酶途径阐明3-羟基吡啶的作用成为可能。
