Amano S, Kreutzberg G W, Reddington M
Acta Neuropathol. 1983;59(2):145-9. doi: 10.1007/BF00691601.
Human astrocytomas contain 5'-nucleotidase as shown using histochemical, cytochemical and biochemical techniques. 5'-Nucleotidase activity was revealed by electron microscopy to be associated with the outer surface of the plasma membrane of astrocytoma cells. The results confirm and extend previous reports of the localisation of 5'-nucleotidase in normal astrocytes in situ. Biochemical assay of 5'-nucleotidase activity in 35 tumours showed it to be clearly higher in malignant (anaplastic astrocytomas and glioblastomas) than in benign astrocytomas.
利用组织化学、细胞化学和生物化学技术表明，人类星形细胞瘤含有5'-核苷酸酶。通过电子显微镜观察发现，5'-核苷酸酶活性与星形细胞瘤细胞的质膜外表面有关。这些结果证实并扩展了先前关于原位正常星形胶质细胞中5'-核苷酸酶定位的报道。对35个肿瘤的5'-核苷酸酶活性进行生化分析表明，恶性肿瘤（间变性星形细胞瘤和胶质母细胞瘤）中的该酶活性明显高于良性星形细胞瘤。
