十二指肠生长抑素瘤。免疫组织病理学及文献综述。

Duodenal somatostatinoma. Immunohistopathology and review of literature.

作者信息

Kaneko H, Toshima M, Kobayashi H, Kitazawa M, Ito S, Iwanaga T, Kusumoto Y, Fujita T, Nitta H

出版信息

Acta Pathol Jpn. 1983 Jan;33(1):153-8. doi: 10.1111/j.1440-1827.1983.tb02108.x.

DOI:10.1111/j.1440-1827.1983.tb02108.x

Abstract

A case of duodenal somatostatinoma is reported. The patient, a 54-year-old male, had complained of an epigastric pain due to gastric ulcer and a duodenal polyp was unexpectedly found at a gastrectomy. The polyp showed basically tubular adenocarcinoma, with negative argyrophil and argentaffin reactions. By an indirect immunofluorescent examination almost all of the tumor cells were revealed as somatostatin-immunoreactive. Big somatostatin was also positive. Radioimmunoassay of the tumor indicated 6400 pg of somatostatin-like immunoreactivity per milligram of wet tissue. This seems to be the second case of duodenal somatostatinoma, following the case reported by us previously.

摘要

报告了一例十二指肠生长抑素瘤。患者为一名54岁男性，因胃溃疡主诉上腹部疼痛，在胃切除术中意外发现十二指肠息肉。息肉基本表现为管状腺癌，嗜银和亲银反应均为阴性。通过间接免疫荧光检查，几乎所有肿瘤细胞均显示生长抑素免疫反应阳性。大生长抑素也呈阳性。对肿瘤进行放射免疫分析表明，每毫克湿组织中生长抑素样免疫反应性为6400皮克。这似乎是继我们之前报道的病例之后的第二例十二指肠生长抑素瘤。