Divac I, Milivojević Z, Krivokuća Z
Acta Neurobiol Exp (Wars). 1982;42(2):223-5.
The aim of the present experiment was to find out whether lesions in the prefrontal system, produced with kainic acid (KA) would disrupt the pattern of activation of the prefrontal system, determined by the deoxyglucose technique. The activation was induced by injections of penicillin into the prefrontal cortex. There was no difference between the pattern previously described in rats with intact brains and that seen in the present animals pretreated with kainic acid. Thus, the doses of KA which destroy some neurons in the prefrontal system do not interfere with the spread of epileptic activity throughout this system.
本实验的目的是查明用 kainic 酸（KA）造成的前额叶系统损伤是否会扰乱由脱氧葡萄糖技术测定的前额叶系统激活模式。激活是通过将青霉素注入前额叶皮质诱导产生的。在脑完整的大鼠中先前描述的模式与在用 kainic 酸预处理的当前动物中观察到的模式之间没有差异。因此，破坏前额叶系统中一些神经元的 KA 剂量不会干扰癫痫活动在整个该系统中的传播。
