[电刺激室旁核对Long-Evans大鼠和Brattleboro大鼠促肾上腺皮质激素功能的影响]

[Effects of electric stimulation of the para-ventricular nucleus on corticotropin function in Long-Evans and Brattleboro rats].

作者信息

Rey M, Conte-Devolx B, Grillo J M, Castanas E, Mercier G, Boudouresque F, Giraud P, Millet Y, Oliver C

出版信息

C R Seances Acad Sci III. 1982 Dec 6;295(12):697-9.

Abstract

Two peptides have a strong corticotropin releasing factor (CRF) activity: arginine vasopressine (AVP) and a 41-residue peptide (41-CRF). Both peptides are present in high concentration in the PVN of the Rat, a zone of the hypothalamus at which electrical stimulation elicits ACTH release. Since homozygous Brattleboro Rats (Di/Di) congenitally lack endogenous AVP, it was of interest to compare the ACTH and corticosterone release after electrical stimulation of the PVN in Long-Evans (L.E.) and Di/Di Rats. In both L.E. and Di/Di Rats, there is a significant increase in plasma ACTH and corticosterone after electrical stimulation of the PVN. However, corticosterone levels are significantly lower in Di/Di than in L.E. Rats whether the Rats have been stimulated or not. It is concluded that a physiological CRF activity is present in the PVN of Di/Di Rats independently of the CRF like activity of AVP.

摘要

两种肽具有很强的促肾上腺皮质激素释放因子（CRF）活性：精氨酸加压素（AVP）和一种由41个氨基酸残基组成的肽（41-CRF）。这两种肽在大鼠的室旁核（PVN）中均高浓度存在，室旁核是下丘脑的一个区域，电刺激该区域可引发促肾上腺皮质激素（ACTH）释放。由于纯合布拉特洛维大鼠（Di/Di）先天性缺乏内源性AVP，因此比较长-伊文斯（L.E.）大鼠和Di/Di大鼠在电刺激PVN后ACTH和皮质酮的释放情况很有意义。在L.E.大鼠和Di/Di大鼠中，电刺激PVN后血浆ACTH和皮质酮均显著增加。然而，无论大鼠是否受到刺激，Di/Di大鼠的皮质酮水平均显著低于L.E.大鼠。得出的结论是，Di/Di大鼠的PVN中存在一种生理性CRF活性，独立于AVP的类CRF活性。