Allon N, Woody C D
Exp Neurol. 1983 May;80(2):491-7. doi: 10.1016/0014-4886(83)90301-1.
Oscillations of 5 to 15 mV in the membrane potentials of neurons of the sensorimotor cortex of normal, awake cats were produced within 15 to 45 s after intracellular injection of Centruroides sculpturatus (c.s.) venom, but not after control injections of KCl. In every cell injected with c.s. venom, the oscillations eventually gave way to paroxysmal depolarizing shifts of appearance similar to that seen in epileptic cells. The results suggest that cortical epileptiform activity can be produced by the local action of c.s. venom, an agent known to alter the gating mechanism of sodium channels. Disruption of sodium gating may represent an intrinsic cellular mechanism involved in epileptogenesis.
正常清醒猫的感觉运动皮层神经元的膜电位在细胞内注射雕塑异距蝎（c.s.）毒液后15至45秒内出现5至15毫伏的振荡，但在注射氯化钾作为对照后未出现这种情况。在每一个注射了c.s.毒液的细胞中，振荡最终都会让位于阵发性去极化偏移，其表现类似于在癫痫细胞中看到的情况。结果表明，c.s.毒液的局部作用可产生皮质癫痫样活动，c.s.毒液是一种已知会改变钠通道门控机制的物质。钠门控的破坏可能代表了癫痫发生所涉及的一种内在细胞机制。
