组胺在体外可使海马锥体细胞产生对钙离子敏感的去极化。

Histamine produces a Ca2+-sensitive depolarization of hippocampal pyramidal cells in vitro.

作者信息

Segal M

出版信息

Neurosci Lett. 1980 Aug;19(1):67-71. doi: 10.1016/0304-3940(80)90257-8.

Abstract

Electrophysiological activity was recorded intracellularly from pyramidal neurons in rat hippocampal slices. Topical application of histamine produced a slow depolarization that was not associated with conductance changes. The depolarization was accompanied by an increase in the rate of action potential discharges. These effects were markedly reduced in slices maintained in a low Ca2+, high Mg2+ medium, indicating that histamine may act presynaptically on hippocampal pyramidal neurons.

摘要

在大鼠海马切片中，从锥体神经元细胞内记录电生理活动。局部应用组胺会产生缓慢去极化，且这与电导变化无关。去极化伴随着动作电位发放速率的增加。在低钙、高镁培养基中维持的切片中，这些效应明显减弱，表明组胺可能在海马锥体神经元的突触前起作用。