Bill G, Jacquet A F, Burckhardt P
Schweiz Med Wochenschr. 1983 Mar 5;113(9):327-30.
The analysis of nephrogenous cyclic AMP (NcAMP) has been reported to be a means of estimating parathyroid function with the advantage of being rapidly and easily performed. More specific than the analysis of urinary cyclic AMP (UcAMP), it measures biological activity of the parathyroid hormone. This study tests its use in the diagnosis of primary hyperparathyroidism (HPP) and compares the results of UcAMP with those of NcAMP. Analyses of NcAMP and parathyroid hormone were performed in a group of 21 healthy controls and two groups of hypercalcemic patients, one consisting of 12 patients with HPP and the other of 14 patients with hypercalcemia of non-parathyroid origin (HCa). It was confirmed that NcAMP is a parameter of parathyroid function, analysis of which allows the diagnosis of HPP with the same precision as analysis of the carboxyterminal plasma PTH. It has the added advantage over PTH measurements of detecting low values, thus permitting documentation of parathyroid inhibition in HCa patients.
据报道，肾源性环磷酸腺苷（NcAMP）分析是一种评估甲状旁腺功能的方法，具有快速、简便的优点。它比尿环磷酸腺苷（UcAMP）分析更具特异性，可测量甲状旁腺激素的生物活性。本研究测试了其在原发性甲状旁腺功能亢进症（HPP）诊断中的应用，并比较了UcAMP和NcAMP的检测结果。对21名健康对照者以及两组高钙血症患者进行了NcAMP和甲状旁腺激素分析，其中一组12例HPP患者，另一组14例非甲状旁腺来源的高钙血症（HCa）患者。结果证实，NcAMP是甲状旁腺功能的一个参数，对其分析可像分析血浆羧基末端甲状旁腺激素（PTH）一样精确地诊断HPP。与PTH测量相比，它还有一个额外的优势，即能检测到低值，从而可记录HCa患者的甲状旁腺抑制情况。
