锂与糖尿病大鼠多巴胺受体超敏反应的预防
Lithium and the prevention of dopamine receptor supersensitivity in diabetic rats.
作者信息
Lozovsky D, Saller C F, Kopin I J
出版信息
Am J Psychiatry. 1983 May;140(5):613-4. doi: 10.1176/ajp.140.5.613.
PMID:6303136
Abstract
Dopamine receptors were increased in rats made diabetic by alloxan; however, chronic lithium treatment substantially reduced the number of dopamine receptors. These findings may be relevant to the effects of lithium in psychiatric disorders.
摘要
用四氧嘧啶使大鼠患糖尿病后，多巴胺受体增加；然而，长期锂治疗可显著减少多巴胺受体数量。这些发现可能与锂在精神疾病中的作用有关。
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