Chichenkov O N
Farmakol Toksikol. 1975 May-Jun;38(3):281-5.
Acute tests on spinal cats were set up to enquire into the effect produced by sodium oxybutyrate, hexobarbital sodium and viadril used in anesthetic doses on the evoked responses in the ventrolateral columns of the spinal cord following stimulation of the skin and pelvic nerves with single and paired stimuli at an interval of 100 msec. Sodium oxybutyrate forces the amplitude of both the evoked responses after the paired stimulation below the initial level by 40-70 per cent. Hexobarbital sodium and viadril, without changing noticeably the amplitude of the first response, are instrumental in reducing the second one by as much as 30-40 per cent. The responses obtained on stimulation of the pelvic nerve are more sensitive to the test substances than are those evoked by the stimulation of the skin nerve.
为了探究麻醉剂量的羟丁酸钠、戊巴比妥钠和利多卡因对脊髓腹外侧柱在以100毫秒间隔的单次和成对刺激皮肤及盆腔神经后诱发反应的影响，对脊髓猫进行了急性试验。羟丁酸钠使成对刺激后的诱发反应幅度比初始水平降低40% - 70%。戊巴比妥钠和利多卡因在未显著改变第一个反应幅度的情况下，可使第二个反应幅度降低多达30% - 40%。刺激盆腔神经所获得的反应比刺激皮肤神经所诱发的反应对受试物质更为敏感。
