Novikov N N
Farmakol Toksikol. 1982 Sep-Oct;45(5):34-8.
It was established in experiments on spinal rats that imizine (2.5-10 mg/kg) decreased spontaneous activity and that evoked by stimulation of the sciatic nerve and intraarterial injection of bradykinin in the dorsal horns and ventrolateral columns of the spinal cord. Transamine (1-5 mg/kg) reduced the evoked activity in the dorsal horns and ventrolateral columns but potentiated spontaneous activity in these structures. Naloxone (1 mg/kg) reduced the effect of imizine (5 mg/kg) on the bradykinin-induced nociceptive activity in the ventrolateral columns of the spinal cord.
在对脊髓大鼠的实验中发现，咪嗪（2.5 - 10毫克/千克）可降低自发活动以及由坐骨神经刺激和动脉内注射缓激肽在脊髓背角和腹外侧柱所诱发的活动。转胺（1 - 5毫克/千克）可降低背角和腹外侧柱的诱发活动，但增强这些结构中的自发活动。纳洛酮（1毫克/千克）可降低咪嗪（5毫克/千克）对脊髓腹外侧柱中缓激肽诱导的伤害性活动的影响。
