[Effect of imizin and transamine on the bioelectrical activity of the ventrolateral columns of the spinal cord].

It was established in experiments on spinal rats that imizine (2.5-10 mg/kg) decreased spontaneous activity and that evoked by stimulation of the sciatic nerve and intraarterial injection of bradykinin in the dorsal horns and ventrolateral columns of the spinal cord. Transamine (1-5 mg/kg) reduced the evoked activity in the dorsal horns and ventrolateral columns but potentiated spontaneous activity in these structures. Naloxone (1 mg/kg) reduced the effect of imizine (5 mg/kg) on the bradykinin-induced nociceptive activity in the ventrolateral columns of the spinal cord.