黑质纹状体多巴胺耗竭性损伤、膈下迷走神经切断术大鼠及其联合手术大鼠的饮食模式。

Meal patterns in rats with nigrostriatal dopamine-depleting lesions, subdiaphragmatic vagotomy, and their combination.

作者信息

Rowland N

出版信息

Brain Res Bull. 1978 Jan-Feb;3(1):89-91. doi: 10.1016/0361-9230(78)90065-5.

Abstract

Rats which had sustained 97% bilateral striatal dopamine depletions after intranigral 6-hydroxydopamine recovered feeding and drinking to show normal meal patterns on both solid and liquid food. The motor acts of eating were somewhat slow but, in contrast to lateral hypothalamic lesioned animals, there were no interruptions for other activities. Vagotomy produced the expected decrease in liquid meal size, and an identical change was observed when the dopamine-depleted rats were similarly vagotomized. The fragmented meal patterns seen after far-lateral hypothalamic lesions do not arise from damage to either of the systems here investigated.

摘要

经黑质内注射6-羟基多巴胺造成双侧纹状体97%多巴胺耗竭的大鼠恢复了进食和饮水，在固体和液体食物上均表现出正常的进食模式。进食的运动动作有些缓慢，但与下丘脑外侧损伤的动物不同，没有因其他活动而中断。迷走神经切断术使液体餐量出现预期的减少，当对多巴胺耗竭的大鼠进行同样的迷走神经切断术时，也观察到了相同的变化。下丘脑远外侧损伤后出现的不连续进食模式并非源于此处所研究的任何一个系统的损伤。