Stanton L W, Watt R, Marcu K B
Nature. 1983;303(5916):401-6. doi: 10.1038/303401a0.
Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or intron. In the plasmacytoma truncated c-myc RNAs initiate from newly exposed promoter sites. Nevertheless, the myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene because the exon lost by breakage and translocation is non-coding. The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29.
对鼠浆细胞瘤中重排的c-myc基因与正常脾脏的c-myc cDNA进行的比较核苷酸序列分析表明，浆细胞瘤中的染色体易位在第一个外显子或内含子内打断了c-myc基因。在浆细胞瘤中，截短的c-myc RNA从新暴露的启动子位点起始。然而，浆细胞瘤中产生的myc多肽可能与完整c-myc基因产生的相同，因为断裂和易位丢失的外显子是非编码的。小鼠c-myc基因的第二和第三外显子在禽逆转录病毒MC29的v-myc基因中基本保守。
