Luttinger D, Frye G D, Nemeroff C B, Prange A J
Psychopharmacology (Berl). 1983;79(4):357-63. doi: 10.1007/BF00433418.
The effects of the three peptides neurotensin, beta-endorphin, and bombesin on ethanol-induced behaviors were studied in mice. Intracisternal administration of these peptides to mice prolonged the duration of sleep induced by ethanol (5.2 g/kg). Neurotensin and beta-endorphin also enhanced ethanol-induced hypothermia. None of the peptides, when administered alone, produced sleep. However, all three compounds impaired the aerial righting reflex and induced sleep when followed by an IP dose of ethanol (3.5 g/kg), which alone did not induce sleep. These results, taken together with previous findings, suggest that neuropeptides may be involved in the complex mechanisms of action of ethanol on the CNS.
研究了三种肽——神经降压素、β-内啡肽和蛙皮素对小鼠乙醇诱导行为的影响。向小鼠脑池内注射这些肽可延长乙醇（5.2克/千克）诱导的睡眠时间。神经降压素和β-内啡肽还增强了乙醇诱导的体温过低。单独注射这些肽均不会产生睡眠。然而，当腹腔注射乙醇（3.5克/千克，单独使用该剂量不会诱导睡眠）后，这三种化合物均会损害空中翻正反射并诱导睡眠。这些结果与之前的研究结果共同表明，神经肽可能参与了乙醇对中枢神经系统作用的复杂机制。
