钩吻与焦虑症和实验神经病学中的补充与替代医学
On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology.
机构信息
Department of Medicine, Univerity of Verona, LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134, Verona, Italy.
出版信息
Neurol Ther. 2015 Jun;4(1):1-10. doi: 10.1007/s40120-014-0025-6. Epub 2014 Dec 19.
Abstract
A recent discussion expanded the debate about the experimental research on Gelsemium in anxiety. Herbal medicine is widely used in anxiety and mood disorders, often with contradictory evidence, although some authors are yet prompted to promote their full introduction in pharmacology as a promising therapy. Complementary and alternative medicine (CAM) in anxiety is particularly appreciated by individual healthcare, but deserves further investigation, as many critical issues have been recently raised. Comments about the ability of negligible doses of Gelsemium hydroalcoholic extracts to affect gene expression were recently reported.
摘要
最近的一次讨论扩大了关于钩吻素在焦虑症实验研究的争论。草药在焦虑症和情绪障碍中被广泛应用，尽管一些作者仍在促使其作为一种有前途的治疗方法在药理学中全面引入，但证据往往相互矛盾。焦虑症的补充和替代医学（CAM）尤其受到个体医疗保健的青睐，但值得进一步研究，因为最近提出了许多关键问题。最近有报道称，极少量钩吻素水醇提取物能够影响基因表达。
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本文引用的文献
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Eur J Pharmacol. 2015 Jan 5;746:252-7. doi: 10.1016/j.ejphar.2014.11.024. Epub 2014 Nov 27.
2
Gene expression and highly diluted molecules.基因表达与高度稀释的分子。
Front Pharmacol. 2014 Nov 12;5:237. doi: 10.3389/fphar.2014.00237. eCollection 2014.
3
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J Cancer Prev. 2014 Mar;19(1):39-46. doi: 10.15430/jcp.2014.19.1.39.
4
High diluted molecules and gene expression.
Front Pharmacol. 2014 Aug 14;5:183. doi: 10.3389/fphar.2014.00183. eCollection 2014.
5
Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist.在存在γ-氨基丁酸能激动剂的情况下，向仓鼠外侧杏仁核注射食欲素-A或食欲素-B所产生的明显的致焦虑/抗焦虑作用。
Neuroreport. 2014 Aug 20;25(12):932-7. doi: 10.1097/WNR.0000000000000213.
6
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