Armitage J O, Burns C P, Kent T H
Cancer. 1978 Feb;41(2):737-42. doi: 10.1002/1097-0142(197802)41:2<737::aid-cncr2820410246>3.0.co;2-7.
Eight adults who developed persisting liver function abnormalities during remission from acute leukemia (6 acute nonlymphoblastic leukemia and 2 acute lymphoblastic leukemia) are reported. These patients constituted 20% of the adults with acute leukemia attaining remission over the time period studied. Although we were unable to be absolutely certain of the etiology of the liver dysfunction, the following findings characterize the problem: 1) onset following red blood cell and platelet transfusions in all cases; 2) minimal symptoms and signs except for transient episodes of jaundice; 3) fluctuating, but often marked, increases in liver transaminases; 4) no other consistent laboratory abnormalities; 5) liver biopsies showing varying degrees of inflammation; 6) a consistent decrease in transaminase levels following pulse chemotherapy; 7) absence of progression of abnormalities during the observation period. This group of patients did not have a worse prognosis than patients with normal liver function. We feel that it is important to recognize this entity and to not withhold antileukemic therapy.
本文报告了8例在急性白血病缓解期出现持续肝功能异常的成人患者（6例急性非淋巴细胞白血病和2例急性淋巴细胞白血病）。在研究期间达到缓解的成人急性白血病患者中，这些患者占20%。尽管我们无法绝对确定肝功能障碍的病因，但以下发现可描述该问题：1）所有病例均在输注红细胞和血小板后发病；2）除短暂黄疸发作外，症状和体征轻微；3）肝转氨酶波动但常显著升高；4）无其他一致的实验室异常；5）肝活检显示不同程度的炎症；6）脉冲化疗后转氨酶水平持续下降；7）观察期内异常无进展。这组患者的预后并不比肝功能正常的患者差。我们认为，认识到这一实体并不要停止抗白血病治疗很重要。
