阿霉素在红细胞中产生羟基自由基的过程。
The production of hydroxyl radicals by adriamycin in red blood cells.
作者信息
Bannister J V, Thornalley P J
出版信息
FEBS Lett. 1983 Jun 27;157(1):170-2. doi: 10.1016/0014-5793(83)81139-9.
PMID:6305715
Abstract
Spin trapping of the free radicals formed from the interaction between adriamycin and red blood cells resulted in the formation of a hydroxyl spin adduct. The formation of hydroxyl radicals was found to be inhibited by mannitol. Hemoglobin was found not to be obligatory for the formation of hydroxyl radicals which probably result from the reduction of hydrogen peroxide by adriamycin semiquinone.
摘要
阿霉素与红细胞相互作用形成的自由基的自旋捕获导致了羟基自旋加合物的形成。发现甘露醇可抑制羟基自由基的形成。发现血红蛋白对于羟基自由基的形成不是必需的，羟基自由基可能是由阿霉素半醌还原过氧化氢产生的。
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