Kracht J, Weber E G
Cell Tissue Res. 1978 Feb 24;187(2):305-13. doi: 10.1007/BF00224372.
In the newt, Notophthalmus viridescens, hypophysectomy results in progressive atrophy of the thyroid cells to the point of irreversible degeneration. After exclusive TSH-stimulation of hypophysectomized newts, increased endocytotic activity of the follicular epithelium is observed. Prolactin stimulation under the same conditions prevents atrophy but does not result in increased cell activity, as expressed by the reduced amount of microvilli and the lack of endocytotic activity. Combined TSH- and prolactin stimulation also results in cell activation, but the activation level of exclusively TSH-stimulated cells is not reached. Although prolactin prevents cellular atrophy and degeneration of the follicular epithelium, it reduces the TSH-induced activation of the thyroid epithelium.
在蝾螈（绿红东美螈，Notophthalmus viridescens）中，垂体切除会导致甲状腺细胞逐渐萎缩，直至发生不可逆的退化。对垂体切除的蝾螈仅用促甲状腺激素（TSH）刺激后，观察到滤泡上皮的内吞活性增加。在相同条件下，催乳素刺激可防止萎缩，但不会导致细胞活性增加，这表现为微绒毛数量减少和缺乏内吞活性。促甲状腺激素和催乳素联合刺激也会导致细胞活化，但未达到仅用促甲状腺激素刺激的细胞的活化水平。尽管催乳素可防止滤泡上皮细胞萎缩和退化，但它会降低促甲状腺激素诱导的甲状腺上皮细胞活化。
