Wilson H E, Stanley K, Vincent R G, Mountain C F, Sealy R, Cohen M, Chen T Y, Batley F, Kilman J, Kakos G, Vasko J, Williams T E, Tucker R D
J Surg Oncol. 1983 Jul;23(3):181-4. doi: 10.1002/jso.2930230312.
In a randomized study 145 patients with extensive small cell carcinoma of the lung were treated with chemotherapy alone (Cytoxan, CCNU, methotrexate) or with the same drug regimen and with radiation therapy to the brain, chest, and abdomen. One hundred eighteen of these patients were evaluable. Those patients receiving radiation had a better response rate (55% vs 31%, P = .016) but significantly greater toxicity. There was no significant difference in rates of complete response (7% vs 8%) or in survival (median 18.4 vs 15.3 weeks) between the two groups overall. The median survival of those patients with a partial response to therapy was 18 weeks; for those achieving a complete response it was 46 weeks. However, a clear difference in survival comparing responders with non-responders was evident only for patients who were assigned to chemotherapy alone. Partial regressions have little, if any, correlation with improvement in survival. Therapy in this disease must be oriented toward inducing complete response.
在一项随机研究中，145例广泛性小细胞肺癌患者接受单纯化疗（环磷酰胺、洛莫司汀、甲氨蝶呤）或相同药物方案联合脑、胸部及腹部放射治疗。其中118例患者可进行评估。接受放疗的患者缓解率更高（55%对31%，P = 0.016），但毒性显著更大。两组总体完全缓解率（7%对8%）或生存率（中位生存期18.4周对15.3周）无显著差异。对治疗有部分缓解的患者中位生存期为18周；达到完全缓解的患者为46周。然而，仅在单纯接受化疗的患者中，有反应者与无反应者的生存率存在明显差异。部分缓解与生存率改善几乎没有相关性（如果有也很微弱）。该疾病的治疗必须以诱导完全缓解为导向。
