伏隔核中的多巴胺耗竭可减少促肾上腺皮质激素1-24诱导的过度梳理行为。
Dopamine depletion in nucleus accumbens reduces ACTH1-24-induced excessive grooming.
作者信息
Springer J E, Isaacson R L, Ryan J P, Hannigan J H
出版信息
Life Sci. 1983 Jul 18;33(3):207-11. doi: 10.1016/0024-3205(83)90378-8.
Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.
动物预先接受向伏隔核注射6-羟基多巴胺或抗坏血酸载体处理，并于10天后进行测试，以检测脑室内注射促肾上腺皮质激素1-24所诱导的过度梳理行为。预先接受6-羟基多巴胺处理的动物，其由神经肽引起的过度梳理行为显著减少，且这种减少仅在60分钟测试期的最后30分钟出现。结果表明，促肾上腺皮质激素与多巴胺系统在过度梳理行为的起始和维持方面存在相互作用。
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