血小板衍生生长因子在结构上与猿猴肉瘤病毒假定的转化蛋白p28sis相关。
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
作者信息
Waterfield M D, Scrace G T, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C H, Huang J S, Deuel T F
出版信息
Nature. 1983;304(5921):35-9. doi: 10.1038/304035a0.
DOI:10.1038/304035a0
PMID:6306471
Abstract
A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
摘要
已确定人血小板衍生生长因子（血清中对间充质来源细胞起主要促有丝分裂作用的因子）的部分氨基酸序列。104个连续氨基酸的区域与猿猴肉瘤病毒（SSV）假定的转化蛋白p28sis的预测序列几乎完全相同。这种相似性提示了SSV及其他因子的转化机制，涉及生长因子的表达。
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