酮康唑混悬液在婴幼儿及儿童中的药理学
Pharmacology of ketoconazole suspension in infants and children.
作者信息
Ginsburg C M, McCracken G H, Olsen K
出版信息
Antimicrob Agents Chemother. 1983 May;23(5):787-9. doi: 10.1128/AAC.23.5.787.
Abstract
The pharmacokinetics of ketoconazole administered as either a commercially prepared suspension or as a crushed tablet in applesauce were studied in 12 children. The mean peak plasma concentration of ketoconazole and the area under the plasma time-concentration curve were approximately twofold greater with the suspension than with the crushed tablets.
摘要
在12名儿童中研究了酮康唑以市售制剂混悬液或制成苹果酱的压碎片剂形式给药后的药代动力学。酮康唑的平均血浆峰浓度和血浆时间-浓度曲线下面积，混悬液给药时约是压碎片剂给药时的两倍。
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本文引用的文献
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Rev Infect Dis. 1980 Jul-Aug;2(4):656-60. doi: 10.1093/clinids/2.4.656.
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Arch Dermatol. 1980 Oct;116(10):1137-41.
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