Fantone J C, Kinnes D A
Biochem Biophys Res Commun. 1983 Jun 15;113(2):506-12. doi: 10.1016/0006-291x(83)91754-0.
15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human neutrophils stimulated with either phorbol myristate acetate or arachidonic acid. These data suggest that the production of superoxide anion by human neutrophils may be mediated by at least two mechanisms, one regulated by prostaglandins and intracellular cyclic adenosine monophosphate levels and a second independent of prostaglandin modulation.
15(S)-15-甲基前列腺素E1和前列腺素I2可快速且可逆地抑制人中性粒细胞由甲酰甲硫氨酰亮氨酰苯丙氨酸诱导产生超氧化物。相比之下，15(S)-15-甲基前列腺素E1和前列腺素I2并不改变佛波酯或花生四烯酸刺激的人中性粒细胞产生超氧化物的速率或总量。这些数据表明，人中性粒细胞产生超氧阴离子可能至少由两种机制介导，一种由前列腺素和细胞内环磷酸腺苷水平调节，另一种则独立于前列腺素调节。
