Suda T, Tomori N, Tozawa F, Mouri T, Demura H, Shizume K
Endocrinology. 1983 Sep;113(3):1182-4. doi: 10.1210/endo-113-3-1182.
Immunoreactive ACTH (I-ACTH) concentrations in the anterior pituitary (AP), intermediate-posterior pituitary (IP) and plasma, and immunoreactive corticotropin-releasing factor (I-CRF) concentrations in the median eminence (ME) and IP, were determined in adrenalectomized rats from 3 h till 14 days after surgery. Plasma I-ACTH concentrations showed the typical triphasic response over time. AP I-ACTH concentrations decreased immediately after surgery, then increased to high concentrations 3 days after surgery. I-ACTH concentrations in IP did not change through these periods. I-CRF concentrations in ME and IP decreased immediately after surgery, then gradually increased to high concentrations (ME) or to control levels (IP) 14 days after surgery. These results raise the possibility that the I-CRF in IP is of hypothalamic origin.
在肾上腺切除的大鼠术后3小时至14天期间，测定其垂体前叶（AP）、垂体中间部-后叶（IP）和血浆中免疫反应性促肾上腺皮质激素（I-ACTH）的浓度，以及正中隆起（ME）和IP中免疫反应性促肾上腺皮质激素释放因子（I-CRF）的浓度。血浆I-ACTH浓度随时间呈现典型的三相反应。术后AP的I-ACTH浓度立即下降，然后在术后3天升至高浓度。在此期间IP的I-ACTH浓度没有变化。术后ME和IP的I-CRF浓度立即下降，然后在术后14天逐渐升至高浓度（ME）或恢复到对照水平（IP）。这些结果提示IP中的I-CRF可能起源于下丘脑。
