用两性离子去污剂溶解脑苯二氮䓬受体：最佳保留其与GABA受体的功能相互作用。
Solubilization of brain benzodiazepine receptors with a zwitterionic detergent: optimal preservation of their functional interaction with the GABA receptors.
作者信息
Mernoff S T, Cherwinski H M, Becker J W, de Blas A L
出版信息
J Neurochem. 1983 Sep;41(3):752-8. doi: 10.1111/j.1471-4159.1983.tb04804.x.
Abstract
Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional detergents.
摘要
在[³H]氟硝西泮与苯二氮䓬受体结合受γ-氨基丁酸（GABA）刺激作用保持完整的条件下，利用两性离子去污剂3-[(3-胆酰胺丙基)二甲基铵]-1-丙磺酸（CHAPS）溶解大鼠脑苯二氮䓬受体。使用其他传统去污剂时，这种刺激作用会部分或完全消失。
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