眼咽型肌营养不良症中的核内包涵体。6例超微结构研究
Nuclear inclusions in oculopharyngeal dystrophy. An ultrastructural study of six cases.
作者信息
Coquet M, Vallat J M, Vital C, Fournier M, Barat M, Orgogozo J M, Julien J, Loiseau P
出版信息
J Neurol Sci. 1983 Jul;60(1):151-6. doi: 10.1016/0022-510x(83)90134-x.
PMID:6308176
Abstract
Nuclear inclusions in striated muscle from patients with oculopharyngeal dystrophy have been detected recently. We carried out ultrastructural examinations of biopsy specimens on 5 patients with oculopharyngeal dystrophy and we also reexamined a former case. In these 6 cases we found filamentous inclusions in a few nuclei. These inclusions seem to be characteristic of this disease as they have never been seen elsewhere.
摘要
最近在眼咽型肌营养不良患者的横纹肌中检测到核内包涵体。我们对5例眼咽型肌营养不良患者的活检标本进行了超微结构检查，还重新检查了1例之前的病例。在这6例病例中，我们在少数细胞核中发现了丝状包涵体。这些包涵体似乎是这种疾病的特征，因为在其他地方从未见过。
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