Hodler J, Roulin F, Haldimann B
Nephrologie. 1983;4(2):60-3.
Six healthy young volunteers were fed during two period of 9 days each by a strictly constantly liquid formula diet (Fresubin), on an ambulator basis. In a single blind cross-over randomized study, they were given either hydrochlorothiazide, 50 mg p.d., or a placebo during the first seven days of the two periods. The diuretic did not induce significant changes of either magnesemia or magnesiuria. In addition, the magnesium excretion after a challenging intravenous magnesium load remained unchanged. However, the thiazide normally increased the urinary excretion of sodium and potassium. It also induced hypocalciuria and hypercalcemia. The urinary excretion of cAMP and oxalic acid remained stable.
六名健康的年轻志愿者在门诊基础上，分两个为期9天的阶段接受严格的常量流质配方饮食（能全力）喂养。在一项单盲交叉随机研究中，在两个阶段的前七天，他们分别服用每日50毫克的氢氯噻嗪或安慰剂。利尿剂并未引起血镁或尿镁的显著变化。此外，静脉注射镁负荷激发后的镁排泄量保持不变。然而，噻嗪类药物通常会增加钠和钾的尿排泄量。它还会导致尿钙减少和血钙升高。环磷酸腺苷和草酸的尿排泄量保持稳定。
