Imanaga H, Yamamoto M, Jimbo M, Kobayashi N, Saito Y, Kitamura K
No Shinkei Geka. 1983 May;11(5):481-8.
The aim of this report is to assess the possibility of digital processing of computed tomography for histological diagnosis of brain tumors. For this purpose, percent histograms of x-ray attenuation value of lesions were analysed in 113 cases of histologically verified hemispheric tumors. Sixteen histograms obtained from normal brain parenchyma served as controls. Histograms were made from the same slices before and after contrast enhancement. The result were as follows; Histograms of benign tumors such as meningiomas and low grade astrocytomas characteristically showed similar pattern with normal subjects, whereas histographic patterns of the more malignant tumors such as malignant astrocytomas, metastases and glioblastomas were more heterogeneous with lower peak and wider curve. Displacement of the histogram to the higher density following contrast material administration was important clue in histographic analysis. The most prominent displacement was observed in meningiomas, followed by metastases with nodular type enhancement and malignant astrocytomas. Displacement in low grade astrocytomas and oligodendrogliomas was very slight and less than that of normal brain. Tumors showing ring enhancement such as glioblastomas and brain abscesses had wide histogram curve with twin peaks. Conclusively, it is possible to detect histological nature of cerebral tumors through CT scanning, using histographic analysis of the digital data.
本报告旨在评估计算机断层扫描数字处理用于脑肿瘤组织学诊断的可能性。为此，对113例经组织学证实的半球肿瘤患者病变的X线衰减值百分比直方图进行了分析。从正常脑实质获取的16个直方图作为对照。直方图由增强前后的相同切片制成。结果如下：脑膜瘤和低级别星形细胞瘤等良性肿瘤的直方图与正常受试者特征性地显示出相似模式，而恶性程度更高的肿瘤如恶性星形细胞瘤、转移瘤和胶质母细胞瘤的直方图模式则更不均匀，峰值更低且曲线更宽。造影剂注入后直方图向更高密度的移位是直方图分析中的重要线索。在脑膜瘤中观察到最明显的移位，其次是结节型强化的转移瘤和恶性星形细胞瘤。低级别星形细胞瘤和少突胶质细胞瘤的移位非常轻微，且小于正常脑。表现为环形强化的肿瘤如胶质母细胞瘤和脑脓肿有宽的直方图曲线和双峰。总之，通过对数字数据进行直方图分析，利用CT扫描检测脑肿瘤的组织学性质是可能的。
