Hansen L G
Neurotoxicology. 1983 Spring;4(1):97-111.
In summary, although there is considerable information on he biotransformation of OP compounds, there are some deficiencies in our knowledge of the biotransformation of phosphonothionate delayed neurotoxicants. Various anomalies, such as the species variations, limited absorption and unique disposition, phenyl phosphonothionate vs. alkyl phosphonothionate potency, O-methyl phenylphosphonothionate vs. O-ethyl phenylphosphonothionate potency, and the relative contributions of various activation and detoxication pathways still exist. The understanding of the syndrome of delayed neurotoxicity will come from receptor/mechanism studies, but by increasing our knowledge of comparative biotransformation, we can insure that our concepts are less distorted by "extraneous" influences. Moreover, since the ultimate goal is to define the syndrome as it relates to the whole organism for predictive and safety considerations, influences such as biotransformation and disposition are no longer extraneous but critical.
总之，尽管关于有机磷化合物的生物转化已有大量信息，但我们对硫代磷酸酯类迟发性神经毒剂的生物转化的了解仍存在一些不足。各种异常情况仍然存在，例如物种差异、吸收有限和独特的处置方式、苯基硫代磷酸酯与烷基硫代磷酸酯的效力、O-甲基苯基硫代磷酸酯与O-乙基苯基硫代磷酸酯的效力，以及各种活化和解毒途径的相对贡献。对迟发性神经毒性综合征的理解将来自受体/机制研究，但通过增加我们对比较生物转化的了解，我们可以确保我们的概念较少受到“外部”影响的扭曲。此外，由于最终目标是为了预测和安全考虑而定义与整个生物体相关的综合征，生物转化和处置等影响不再是无关紧要的，而是至关重要的。
