Ahlfors K, Forsgren M, Ivarsson S A, Harris S, Svanberg L
Scand J Infect Dis. 1983;15(2):129-38. doi: 10.3109/inf.1983.15.issue-2.01.
Maternal sera from 45 live-born infants with congenital cytomegalovirus (CMV) infection and 4 cases of legal abortion were analysed for CMV IgG and IgM. The investigation included cases from routine work and prospective studies of unselected infants. The purpose was to elucidate the relation between the maternal type and time of infection and the signs and symptoms of the offspring at birth and follow-up. Serological patterns compatible with primary maternal infection during trimesters I and II, but also with secondary infection (in at least 1 case), were associated with infant sequelae or death. Asymptomatic infant infection was found after primary infection in trimesters II and III and after secondary infection. Virus could not be isolated from some of the fetuses legally aborted due to primary maternal infection in trimester I. Attempts to demonstrate CMV IgM activity as a marker of active infection in sera from early pregnancy (period of legal abortion) were successful in only half of the 10 cases with infant sequelae or death. Symptoms at birth were prognostically serious, but the further course was sometimes uneventful even in infants with neonatal signs of cerebral infection. A few children without initial symptoms developed sequelae (impairment of hearing).
对45例先天性巨细胞病毒（CMV）感染的活产婴儿和4例人工流产病例的母体血清进行了CMV IgG和IgM分析。该调查包括日常工作中的病例以及对未经筛选的婴儿进行的前瞻性研究。目的是阐明母体感染类型和时间与出生时及随访时子代的体征和症状之间的关系。与孕早期和孕中期母体原发性感染相符的血清学模式，以及与继发性感染（至少1例）相符的血清学模式，均与婴儿后遗症或死亡相关。在孕中期和孕晚期原发性感染后以及继发性感染后发现了无症状的婴儿感染。由于孕早期母体原发性感染而合法流产的一些胎儿无法分离出病毒。在10例有婴儿后遗症或死亡的病例中，仅半数成功地将CMV IgM活性作为早期妊娠（人工流产期）血清中活动性感染的标志物进行了检测。出生时的症状预后严重，但即使是有新生儿脑感染体征的婴儿，其后续病程有时也较为平稳。一些最初无症状的儿童出现了后遗症（听力受损）。
