Andreou J, George A E, Wise A, de Leon M, Kricheff I I, Ransohoff J, Foo S H
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):488-90.
The serial pre- and postoperative computed tomographic (CT) scans of 115 patients entered in the Cooperative Brain Tumor Study between 1975 and 1982 were analyzed in order to define CT prognostic criteria and to test the hypothesis that radical glioma surgery prolongs patient survival. The CT parameters of mass size, associated edema, and intensity of enhancement were quantitated on all scans. Clinical parameters evaluated included gender, age, length of survival, and useful (Karnofsky greater than 30) survival. Data analyses indicated postoperative residual tumor burden was inversely related to length of survival (p less than 0.01). Postoperative associated edema and intensity of image enhancement were also of prognostic value and showed an inverse relation to survival. Younger patients proved more likely than older patients to attain long-term survival. Residual tumor burden of less than 45 mm diameter on postoperative CT scans was associated with 70% chance of long-term survival. These findings support the radical surgical management of glioma.
对1975年至1982年间参与脑肿瘤合作研究的115例患者的系列术前和术后计算机断层扫描（CT）进行分析，以确定CT预后标准，并检验根治性胶质瘤手术可延长患者生存期这一假设。对所有扫描图像的肿块大小、相关水肿及强化强度等CT参数进行定量分析。评估的临床参数包括性别、年龄、生存期及有效生存期（卡诺夫斯基评分大于30）。数据分析表明，术后残余肿瘤负荷与生存期呈负相关（p<0.01）。术后相关水肿及图像强化强度也具有预后价值，且与生存期呈负相关。结果证明，年轻患者比老年患者更有可能获得长期生存。术后CT扫描显示直径小于45 mm的残余肿瘤负荷患者有70%的长期生存机会。这些发现支持胶质瘤的根治性手术治疗。
