[多烯抗生素制霉菌素与二价铜离子的相互作用]
[Interaction of the polyene antibiotic nystatin with bivalent copper ions].
作者信息
Komarov E V, Travkin O V, Ivanov G G, Mikhaĭlova M A, Shneĭder M A
出版信息
Antibiotiki. 1983 Jun;28(6):437-41.
PMID:6309076
Abstract
Characteristic features of interaction of nystatin with bivalent copper salts in water, methanol and dimethylsulfoxide were studied. It was shown that stable compounds of copper and nystatin at ratios of 1 : 2 and 1 : 4 formed in the above solvents. The antibiotic in these compounds was in an inert, native or activated state. Physicochemical and biological properties of the compounds were investigated.
摘要
研究了制霉菌素与二价铜盐在水、甲醇和二甲亚砜中的相互作用特征。结果表明，在上述溶剂中形成了铜与制霉菌素比例为1:2和1:4的稳定化合物。这些化合物中的抗生素处于惰性、天然或活化状态。对这些化合物的物理化学和生物学性质进行了研究。
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