Tsunemoto H
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt 2):394-401.
Radiation therapy, which has significantly been on progressed by introduction of high energy X-ray and gamma-ray machines, is reaching to a turning point in order to improve further the results of the treatment. The treatment with particle radiations, characterized by either the high energy transfer to the surrounding tissues or the excellent dose distributions, i.e. Bragg peak, are in clinical trials. The results up to date show that the locally advanced, and radioresistant cancers have been more successfully controlled by applying fast neutrons than use of x-rays and that the damage to the normal tissues was less in the proton therapy compared with the conventional radiations. It is suggested from this clinical trial that the effect of particle radiations be more enhanced when the heavy ions, i.e., Neon ions and Silicon ions, become available.
随着高能X射线和伽马射线机器的引入，放射治疗取得了显著进展，目前正处于一个转折点，以便进一步提高治疗效果。以向周围组织传递高能量或具有优异剂量分布（即布拉格峰）为特征的粒子放射治疗正在进行临床试验。迄今为止的结果表明，对于局部晚期和抗辐射癌症，应用快中子比使用X射线能更成功地进行控制，并且与传统放射治疗相比，质子治疗对正常组织的损伤更小。从该临床试验可以看出，当重离子（即氖离子和硅离子）可用时，粒子放射的效果将得到更大增强。
