Interaction of (+/-)-7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with relaxed circular pBR322 DNA.
作者信息
Agarwal K L, Hrinyo T P, Yang N C
出版信息
Biochem Biophys Res Commun. 1983 Jul 18;114(1):14-9. doi: 10.1016/0006-291x(83)91587-5.
PMID:6309162
Abstract
The interaction of (+/-)-BPDE (1) with DNA at neutral pH was investigated by the application of relaxed circular pBR322 DNA. (+/-)-BPDE causes a rapid positive supercoiling of this DNA followed by a slower spontaneous relaxation. The results indicate that there are two clearly discernible types of chemical interactions between 1 and DNA, a rapid intercalative covalent binding and a slower strand breakage. The implications of these findings are discussed.
摘要
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