髓质素在粒细胞炎症发展中的作用。I. 致炎活性及对巨噬细胞和粒细胞功能的影响。
Role of medullasin in granulocytes in the development of inflammation. I. Phlogistic activity and the effect on functions of macrophages and granulocytes.
作者信息
Aoki Y, Machinami R
出版信息
Arthritis Rheum. 1983 Aug;26(8):1002-10. doi: 10.1002/art.1780260809.
PMID:6309191
Abstract
Injection of a small amount of medullasin protease (20 micrograms) into the skin of guinea pigs or rabbits caused inflammation characterized by severe injury to endothelial cells in venules and by infiltration of a large number of macrophages. Medullasin inhibited macrophage chemotaxis in vitro, stimulated granulocyte chemotaxis, and potentiated the production of superoxide by macrophages. These results indicate that medullasin in granulocytes plays an important role in the development of inflammation.
摘要
向豚鼠或兔子的皮肤中注射少量髓质素蛋白酶（20微克）会引发炎症，其特征为小静脉内皮细胞受到严重损伤以及大量巨噬细胞浸润。髓质素在体外抑制巨噬细胞趋化作用，刺激粒细胞趋化作用，并增强巨噬细胞超氧化物的产生。这些结果表明，粒细胞中的髓质素在炎症发展中起重要作用。
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Role of medullasin in granulocytes in the development of inflammation. I. Phlogistic activity and the effect on functions of macrophages and granulocytes.髓质素在粒细胞炎症发展中的作用。I. 致炎活性及对巨噬细胞和粒细胞功能的影响。
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