Heberer M, Ernst M, Dürig M, Harder F
Cancer Detect Prev. 1983;6(1-2):273-80.
Granulocytes and monocytes can attack malignant cells by activated oxygen species. They thereby emit photons which may be measured as chemiluminescence (CL). The zymosan-induced and luminol-amplified CL response of granulocytes and monocytes was measured in diluted whole blood samples of healthy volunteers and patients with benign and malignant disease. In tumor patients the CL activity was significantly stimulated. Following tumor reduction by radical or palliative operations, the CL values decreased to normal within weeks, whereas no response was seen after exploratory laparotomy without tumor reduction. Operations for benign disease did not influence the CL activity. The results suggest that the stimulation of CL activity in tumor patients is reversible. CL measurements in whole blood samples may play a future role as a nonspecific tumor marker.
粒细胞和单核细胞可通过活性氧攻击恶性细胞。它们由此发出光子，这些光子可作为化学发光（CL）进行测量。在健康志愿者以及患有良性和恶性疾病的患者的稀释全血样本中，测量了酵母聚糖诱导的以及鲁米诺增强的粒细胞和单核细胞的CL反应。在肿瘤患者中，CL活性受到显著刺激。在通过根治性或姑息性手术使肿瘤缩小后，CL值在数周内降至正常，而在未进行肿瘤切除的 exploratory laparotomy 后未观察到反应。良性疾病的手术不影响CL活性。结果表明，肿瘤患者中CL活性的刺激是可逆的。全血样本中的CL测量可能在未来作为一种非特异性肿瘤标志物发挥作用。
