Ralph R K
FEBS Lett. 1983 Sep 5;161(1):1-8. doi: 10.1016/0014-5793(83)80719-4.
The role of cyclic AMP and calcium in the control of normal and tumour cell growth is considered in relation to the question whether cyclic AMP is a true mitogen or co-mitogen. It is proposed that cyclic AMP normally controls the cell cycle at a point in G1 phase only by virtue of its ability to exclude calcium required by cells to progress past this point into S phase. Therefore increased influx of calcium by other routes induced by various factors can bypass the inhibitory effect of cyclic AMP and stimulate growth. In these circumstances cyclic AMP or calcium may or may not facilitate further progress into S phase according to the metabolic requirements of individual cells. The relevance to cancer cells is considered.
就环磷酸腺苷（cAMP）是否为真正的促有丝分裂原或协同促有丝分裂原这一问题，探讨了cAMP和钙在正常细胞及肿瘤细胞生长控制中的作用。提出cAMP通常仅在G1期的某一点控制细胞周期，这是因为它能够排除细胞进入S期所需的钙。因此，各种因素诱导的其他途径导致的钙内流增加，可绕过cAMP的抑制作用并刺激生长。在这些情况下，根据单个细胞的代谢需求，cAMP或钙可能促进也可能不促进细胞进一步进入S期。文中还考虑了其与癌细胞的相关性。
