Kvetny J
Diabetologia. 1983 Jun;24(6):428-32. doi: 10.1007/BF00257341.
The number of nuclear thyroxine (T4) or triiodothyronine (T3) receptors and the serum values of thyroxine, triiodothyronine, reverse triiodothyronine and TSH were investigated in 13 patients with Type 1 (insulin-dependent) diabetes (group 1), in 10 patients with Type 2 (non-insulin-dependent) diabetes (group 2) and in age and weight matched non-diabetic subjects. All patients were clinically euthyroid, although serum T3 was low and reverse T3 high in group 1 compared with the non-diabetic subjects. The Type 1 diabetic patients had evidence of poor metabolic control because of weight loss and high glycosylated haemoglobin levels. The maximal specific nuclear binding capacities for T4 (1.8 X 10(-16) mol T4/10 micrograms DNA) and T3 (1.4 X 10(-16) mol T3/10 micrograms DNA) were increased in group 1 compared with the normal subjects (T4: 1.1 X 10(-16) mol T4/10 micrograms DNA, p less than 0.010, T3: 0.9 X 10(-16) mol T3/10 micrograms DNA, p less than 0.05), whereas the nuclear binding affinity for T4 (Ka = 1.5 X 10(9) l/mol) and T3 (5.1 X 10(9) l/mol) was similar to that of the normal subjects (T4, Ka = 2.0 X 10(9) l/mol; T3, Ka = 5.6 X 10(9) l/mol). In contrast, neither the nuclear binding of T4 (1.0 X 10(-16) mol T4/10 micrograms DNA) and T3 (1.1 X 10(-16) mol T3/10 micrograms DNA) nor the binding affinity for T4 (Ka = 3.3 X 10(9) l/mol) and T3 (Ka = 3.9 X 10(9) l/mol) in group 2 differed from those of the non-diabetic subjects. In conclusion, nuclear T4 and T3 receptor number in cells from patients with poorly controlled Type 1 diabetes was raised compared with normal subjects. This increase may have been responsible for the euthyroidism in these patients in whom the serum T3 was low. In contrast, cellular binding of T4 and T3 appeared normal in the Type 2 diabetic subjects.
对13例1型（胰岛素依赖型）糖尿病患者（第1组）、10例2型（非胰岛素依赖型）糖尿病患者（第2组）以及年龄和体重匹配的非糖尿病受试者，研究了甲状腺素（T4）或三碘甲状腺原氨酸（T3）核受体数量以及甲状腺素、三碘甲状腺原氨酸、反三碘甲状腺原氨酸和促甲状腺激素的血清值。所有患者临床甲状腺功能正常，尽管与非糖尿病受试者相比，第1组患者血清T3水平较低，反T3水平较高。1型糖尿病患者因体重减轻和糖化血红蛋白水平升高，有代谢控制不佳的证据。与正常受试者相比，第1组患者T4（1.8×10⁻¹⁶mol T4/10μg DNA）和T3（1.4×10⁻¹⁶mol T3/10μg DNA）的最大特异性核结合能力增加（T4：1.1×10⁻¹⁶mol T4/10μg DNA，p＜0.010；T3：0.9×10⁻¹⁶mol T3/10μg DNA，p＜0.05），而T4（Ka = 1.5×10⁹l/mol）和T3（5.1×10⁹l/mol）的核结合亲和力与正常受试者相似（T4，Ka = 2.0×10⁹l/mol；T3，Ka = 5.6×10⁹l/mol）。相比之下，第2组患者T4（1.0×10⁻¹⁶mol T4/10μg DNA）和T3（1.1×10⁻¹⁶mol T3/10μg DNA）的核结合以及T4（Ka = 3.3×10⁹l/mol）和T3（Ka = 3.9×10⁹l/mol）的结合亲和力与非糖尿病受试者无差异。总之，与正常受试者相比，控制不佳的1型糖尿病患者细胞中的核T4和T3受体数量增加。这种增加可能是这些血清T3水平较低的患者甲状腺功能正常的原因。相比之下，2型糖尿病患者中T4和T3的细胞结合似乎正常。
