Churiukanov V V, Bilibin D P
Farmakol Toksikol. 1976 Mar-Apr;39(2):152-5.
The effect produced by narcotic analgetics with their intravenous administration on the process of cortical control over the transmission of impulses along specific routes of the sciatic nerve was studied. The conditioning stimulation of the cortex was effected by using a monopolar electrode through single electric impulses. The interval between conditioning and test (on sciatic nerve) impulses was of 80-120 ms. Morphine (1-2 mg/kg), promedol (trimeperidin) (1-2 mg/kg) and phentanyl (100 gamma/kg) potentiated the inhibition of evoked potentials in the nucleus gracilis and in VPL, observed upon stimulation of the cortex of optic lobuses. The intensification of inhibitory corticifugal mechanisms occurring under the effect of narcotic analgetics takes place both on the level of the medulla oblongata and of the thalamic one.
研究了静脉注射麻醉性镇痛药对皮质控制坐骨神经特定途径冲动传递过程的影响。通过单极电极利用单个电脉冲对皮质进行条件刺激。条件刺激和测试（对坐骨神经）脉冲之间的间隔为80 - 120毫秒。吗啡（1 - 2毫克/千克）、异丙嗪（三甲哌替啶）（1 - 2毫克/千克）和芬太尼（100微克/千克）增强了在刺激视叶皮质时观察到的薄束核和腹后外侧核中诱发电位的抑制作用。麻醉性镇痛药作用下发生的抑制性皮质离心机制的增强在延髓水平和丘脑水平均有发生。
