Monto A S, Koopman J S, Longini I M, Isaacson R E
J Infect Dis. 1983 Aug;148(2):284-91. doi: 10.1093/infdis/148.2.284.
Enteric illnesses in residents of Tecumseh, Michigan, were studied from 1976 to 1981. The frequency of illness among adults and children increased each year in the late autumn, usually in November. This peak of illness preceded the main period of appearance of the rotaviruses, which were less regularly associated with another peak of illness. Rotaviruses were identified in 3.8% of all stool specimens collected; in specimens from children under two years of age, the annual rate of rotavirus identification was 10.4%. All rotaviruses were identified during the period from late December to early April. Bacterial pathogens were isolated from 3.3% of stool specimens, with no concentration in any age group or season. However, most enteric illnesses in the community were not associated with recognized pathogens. Testing of blood specimens collected in 1976-1978 by complement fixation confirmed the seasonal pattern of rotavirus activity. Rotavirus infections were documented in all age groups, even in older adults, and were associated with symptomatic illness.
1976年至1981年期间，对密歇根州蒂康塞居民的肠道疾病进行了研究。成人和儿童患病频率在每年深秋（通常是11月）都会增加。这种疾病高峰先于轮状病毒出现的主要时期，而轮状病毒与另一个疾病高峰的关联不太规律。在所有收集的粪便标本中，3.8%检测出轮状病毒；在两岁以下儿童的标本中，轮状病毒的年检出率为10.4%。所有轮状病毒均在12月下旬至4月初期间检出。3.3%的粪便标本中分离出细菌病原体，在任何年龄组或季节均无集中现象。然而，该社区的大多数肠道疾病与已确认的病原体无关。通过补体结合试验对1976 - 1978年采集的血液标本进行检测，证实了轮状病毒活动的季节性模式。所有年龄组都有轮状病毒感染记录，甚至在老年人中也是如此，并且与有症状的疾病有关。
