Trueblood B, Judson B A, Goldstein A
Drug Alcohol Depend. 1978 Mar;3(2):125-32. doi: 10.1016/0376-8716(78)90025-x.
Heroin addicts who had been maintained for at least three months on LAAM (levo-alpha-acetylmethadol, methadyl acetate) and at least three months on methadone were asked to compare the two drugs on a number of criteria. The responses were highly selective, indicating that a desire to please the investigators was not an important factor. Overwhelmingly, the majority of patients reported that LAAM provided better heroin "blockade", that it was more effective in reducing craving, and that actual use of heroin was less on LAAM than on methadone. In other respects, such as sexual performance, sleep, and appetite, most patients perceived no difference between the drugs. In no respect was methadone preferred by a majority, although methadone was viewed more favorably on some criteria by some patients. These findings indicate that for most heroin addicts LAAM will be an acceptable maintenance drug.
曾使用左-α-乙酰美沙醇（LAAM，醋酸美沙多）维持治疗至少三个月且使用美沙酮维持治疗至少三个月的海洛因成瘾者被要求根据多项标准对这两种药物进行比较。他们的回答具有高度选择性，这表明取悦研究者的意愿并非重要因素。绝大多数患者压倒性地表示，LAAM能更好地“阻断”海洛因，在减少渴望方面更有效，且与美沙酮相比，使用LAAM时实际的海洛因使用量更少。在其他方面，如性功能、睡眠和食欲，大多数患者认为这两种药物没有差异。尽管一些患者在某些标准上对美沙酮评价更高，但在任何方面，选择美沙酮的患者都未占多数。这些发现表明，对大多数海洛因成瘾者来说，LAAM将是一种可接受的维持治疗药物。
