Genazzani A R, Facchinetti F, Petraglia F, Pintor C, Bagnoli F, Puggioni R, Corda R
J Steroid Biochem. 1983 Jul;19(1C):891-5. doi: 10.1016/0022-4731(83)90030-4.
In 139 prepubertal children and in 38 pubertal adolescents plasma levels of ACTH, cortisol, beta-lipotropin (BLPH), beta-endorphin (BEP) and dehydroepiandrosterone sulphate (DHAS) were determined by specific radioimmunoassays directly (steroids) or after plasma purification (peptides). ACTH and cortisol concentrations remain stable during both prepuberty and puberty, while DHAS levels constantly increased from 5 to 16 years. Both BLPH and BEP increase from early infancy to late prepuberty when they reach adult values. During puberty both opioids remain constantly within the adult range. BLPH and BEP concentrations were significantly correlated to those of DHAS throughout prepuberty. These data suggest a possible role of BLPH and BEP in and/or other proopiocortin-related peptides in the development of adrenarche, while the lack of particular changes in these peptide levels during sexual maturation seems to exclude their role in gonadarche and pubertal development.
通过特定放射免疫测定法直接（针对类固醇）或血浆纯化后（针对肽类），测定了139名青春期前儿童和38名青春期青少年血浆中促肾上腺皮质激素（ACTH）、皮质醇、β-促脂素（BLPH）、β-内啡肽（BEP）和硫酸脱氢表雄酮（DHAS）的水平。ACTH和皮质醇浓度在青春期前和青春期均保持稳定，而DHAS水平从5岁到16岁持续升高。BLPH和BEP从婴儿早期到青春期后期均升高，直至达到成人水平。在青春期，这两种阿片样物质均持续保持在成人范围内。在整个青春期前，BLPH和BEP浓度与DHAS浓度显著相关。这些数据表明，BLPH和BEP及/或其他促阿片皮质素相关肽在肾上腺初现发育中可能发挥作用，而在性成熟过程中这些肽水平缺乏特定变化似乎排除了它们在性腺初现和青春期发育中的作用。
