Lomonosova M V, Savinskaia A P, Molodyk A A, Gorshkova I A
Med Radiol (Mosk). 1983 Aug;28(8):40-4.
A simultaneous determination of 3 gonadotropic hormones of the hypophysis (follitropin, lutronin and prolactin) using a radioimmunoassay in 33 patients with trophoblastic uterine tumors and 22 women on the 1st-8th day after normal delivery, has shown that there are not only significant differences in the nature of the secretion of hypophyseal gonadotropic hormones in pathology as compared to the normal postnatal period but also differences in different forms of trophoblastic tumors. These differences were characterized by a progressive, according to the severity of disease, independence between trophoblastic tissue function and gonadotropic function of the hypophysis. A marked suppression of follicle-stimulating function of the hypophysis after normal delivery decreased hydatidiform mole and trophoblastic tumors and was not observed in patients with chorioepithelioma of the uterus.
采用放射免疫分析法对33例滋养层子宫肿瘤患者及22例正常分娩后第1 - 8天的女性同时测定垂体的3种促性腺激素（促卵泡激素、促黄体激素和催乳素），结果表明，与正常产后时期相比，病理状态下垂体促性腺激素的分泌性质不仅存在显著差异，而且在不同类型的滋养层肿瘤中也存在差异。这些差异的特征是，根据疾病的严重程度，滋养层组织功能与垂体促性腺功能之间逐渐出现独立性。正常分娩后垂体促卵泡功能的显著抑制在葡萄胎和滋养层肿瘤患者中有所降低，而子宫绒毛膜上皮癌患者未观察到这种抑制现象。
