Sirinathsinghji D J, Rees L H, Rivier J, Vale W
Nature. 1983;305(5931):232-5. doi: 10.1038/305232a0.
Corticotropin-releasing factor (CRF), the recently characterized and synthesized 41-amino acid polypeptide isolated from ovine hypothalami, has been shown to be a potent stimulator of adenohypophyseal beta-endorphin and corticotropin (ACTH) secretion both in vitro and in vivo. In common with other regulatory peptides, CRF has also been demonstrated to possess extra-hypophysiotropic roles. Indeed, intracerebroventricularly (i.c.v.) administered CRF elicits several endocrine and behavioural responses compatible with the concept that this peptide could be a key signal in coordinating the organism's endocrine and behavioural responses to stressful and other adaptive stimuli. We now provide the first evidence for neurally placed CRF in the control of a specific hormone-dependent behavioural response and unequivocally demonstrate an extremely potent suppressive effect of CRF on sexual behaviour in the female rat when microinfused into the arcuate-ventromedial area of the hypothalamus (ARC-VMH) and the mesencephalic central grey (MCG).
促肾上腺皮质激素释放因子（CRF）是最近从绵羊下丘脑分离并合成的一种含41个氨基酸的多肽，已证明它在体外和体内都是腺垂体β-内啡肽和促肾上腺皮质激素（ACTH）分泌的有效刺激物。与其他调节肽一样，CRF也被证明具有垂体外作用。实际上，脑室内（i.c.v.）注射CRF会引发多种内分泌和行为反应，这与该肽可能是协调机体对压力和其他适应性刺激的内分泌和行为反应的关键信号这一概念相符。我们现在首次提供了神经定位的CRF在控制特定激素依赖性行为反应中的证据，并明确证明，当微量注入下丘脑弓状腹内侧区（ARC-VMH）和中脑中央灰质（MCG）时，CRF对雌性大鼠的性行为具有极强的抑制作用。
