Pykett I L, Rosen B R
Radiology. 1983 Oct;149(1):197-201. doi: 10.1148/radiology.149.1.6310682.
Using a three-dimensional Fourier transform approach, proton nuclear magnetic resonance (NMR) chemical shift images have been obtained in vivo for the first time. At a proton resonance frequency of 61.5 MHz, chemical shift-resolved images of simple phantoms indicate that a spectral resolution of 0.7 parts per million (ppm) is readily achievable at all locations within the image matrix, even when using a magnet not specifically designed for chemical shift spectroscopy. In vivo images of the human forearm and of a cat head yield separable signals from water and lipid protons. However, using simple radiofrequency pulse sequences, our data show that relatively little signal originates from membrane lipids (e.g., myelin) in the brain. The measurement of magnetic susceptibility using this technique is also demonstrated. While helping to elucidate the genesis of the NMR response in complex biological systems, this methodology also has potential applications in medical diagnosis. The technique is also applicable to the chemical shift imaging of other nuclei; for example, phosphorus (P-31).
通过三维傅里叶变换方法，首次在体内获得了质子核磁共振（NMR）化学位移图像。在61.5 MHz的质子共振频率下，简单体模的化学位移分辨图像表明，即使使用并非专门为化学位移光谱设计的磁体，在图像矩阵内的所有位置都能轻松实现0.7百万分之一（ppm）的光谱分辨率。人体前臂和猫头的体内图像产生了来自水和脂质质子的可分离信号。然而，使用简单的射频脉冲序列，我们的数据表明，大脑中相对较少的信号源自膜脂质（如髓磷脂）。还展示了使用该技术测量磁化率的方法。在有助于阐明复杂生物系统中NMR响应的起源的同时，这种方法在医学诊断中也具有潜在应用。该技术也适用于其他原子核的化学位移成像；例如，磷（P - 31）。
