Globus M, Melamed E
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):211-5. doi: 10.1016/0278-5846(83)90109-4.
The effect of combined administration of L-dopa with apomorphine or with bromocriptine on rat striatal concentrations of dopamine (DA), dihydroxyphenylacetic (DOPAC) and dopa was investigated. Injections of apomorphine or bromocriptine alone decreased striatal DOPAC levels indicating suppression of DA turnover in nigrostriatal terminals. The dopa-induced elevations in striatal concentrations of DA, DOPAC and dopa were similar among animals injected with L-dopa alone or in combination with apomorphine or bromocriptine. These findings suggest that although direct DA receptor agonists decrease striatal DA turnover, they do not interfere with utilization of exogenous L-dopa in striatum.
研究了左旋多巴与阿扑吗啡或溴隐亭联合给药对大鼠纹状体中多巴胺（DA）、二羟基苯乙酸（DOPAC）和多巴浓度的影响。单独注射阿扑吗啡或溴隐亭可降低纹状体DOPAC水平，表明黑质纹状体终末的DA周转受到抑制。在单独注射左旋多巴或与阿扑吗啡或溴隐亭联合注射的动物中，多巴引起的纹状体DA、DOPAC和多巴浓度升高相似。这些发现表明，尽管直接DA受体激动剂可降低纹状体DA周转，但它们并不干扰纹状体中外源性左旋多巴的利用。
